So, I can not help but want to run a campaign basically modeled around the comic "rice boy" (available to view online at rice-boy.com).
((WARNING: CONTAINS SOME SPOILERS OF rice boy))
A lot of aspects of rice boy will be more or less impossible to capture, and would not make for a fun game (after all, the PCs need to be the heroes, not T-O-E and rice boy!) but I thought I would flesh out some of my ideas for a campaign inspired by Overside here.
1. Three Avatars, in place of deities. The Avatars are of Space, Time, and Mind. However, Mind has been missing for several thousand years.
2. A set of "Searchers" who were divinely mandated to seek out the Fulfiller, the one who will bring back the Avatar of Mind and granted immortality in the process. There were originally three searchers. However, one was killed for losing faith and giving up, and the other left long ago and is only kept alive by a the Black Drink, a cursed drink that keeps him alive but more or less kills his soul.
3. A world that is divided into two parts, Overside and Underside (literally the top and bottom of a disk). The only way to travel through the two is via the lost city of Seen, a linking city, and only those given the Mark of Seen are allowed to leave or wander freely. Underside is diseased, due to the creatures that live there bringing a sickness from the void when they arrived.
4. A militant group of frog-people inhabit the southern swampland of the main continent in a place called Sunk. Two generations ago, the Searchers suggested that their ruler's son, Spatch, might be the Fulfiller. The thought drove him mad with delusions of grandeur, and in his rule he turned Sunk into a militant and powerful kingdom. Though he died, without ever fulfilling the Prophecy and bringing back the Avatar of Mind, he wrote a great book passing on the status of Fulfiller to those descended from him, and Sunk continues to operate under the rule of Spatch II, with armies of frog-men more than willing to destroy any who claim to be the Fulfiller.
5. A prophecy was left, thousands of years ago, essentially stating that one day a Fulfiller would rise. This Fulfiller would travel far and to places seldom seen, and change form thrice, before ascending an iron tower. A war would be fought on the foot of the tower, the sky would turn red, the Fulfiller would die, and the Avatar of Mind would return. Very few people know of this prophecy, and no one knows the full details, as it was written in a language only one person (Ridrom the sage) ever deciphered. Ridrom, before dying, set a great immortal beast to select an heir to the secrets. The Heirs of Ridrom (only one exists at a time) carry on the secrets of the Prophecy, of which others know only bits and pieces.
Those would be the elements of rice boy I would intend to keep. A lot of the comic's surreal and magical nature will sadly be lost in D&D, but that's OK. I'm not trying to recreate the comic. I'm just using its elements to create a different story, in which a band of PCs can be the heroes instead.
The party begins near the Matchwoods, home of rice boy. The one remaining Searcher, T-O-E, is also traveling to the Matchwoods in order to speak to rice boy, who he suspects is the Fulfiller. Minor adventures, the party meets T-O-E and briefly meets rice boy, a hint of what is to come. rice boy does not believe he is the Fulfiller and refuses to go on the trip that T-O-E requests. T-O-E leaves.
Later rice boy changes his mind and decides to travel to the Dorlish wood and meet with the Tree-keeper, as T-O-E requested. He travels with the party for safety.
(Up until this point, we're basically following the story line.)
After some adventures getting rice boy to Dorlish wood, have T-O-E rejoin the party, but introduce Golgo/Angel-Eye, former Searcher, and a platoon of frog-men. T-O-E leaves to fight Golgo while the party protects rice boy from the frog men. They return to find T-O-E killed with his own knife, and Golgo escaping but wounded.
Characters from this point on are on their own, escorting rice boy through Overside, and eventually to Underside, aiding him so that he may fulfill the Prophecy. rice boy is unable to defend himself or really do much, so the quest is basically an Artifact Quest (party brings Important Artifact from point A to point B in order to Make Stuff Happen, important bad guys try to get in the way - see Lord of the Rings), except that the Artifact in this case is a child. Party eventually learns things like the fact that, if rice boy is to fulfill this prophecy, he will die. Heavy shit, dogg.
Periodically effects take place, like the water in the Lonely Land turning folks (including rice boy) blue, gradually causing form to change, etc.
Climactic battle for the quest (if I do this at 4e, probably will be early in the epic tier) involves the war in the center of the Circle Sea, the ascent of the Iron Tower, the final battle with Golgo and Spatch II, etc.
If I want, one of the party members can, in fact, be the true Fulfiller, but without discovering that until they are atop the Iron Tower. It helps that no one in my current gaming group has read rice boy. If they have, I'll perhaps switch things up a little.
Those are basic thoughts on the campaign I'm creating. Most things are still in my head, but if anyone has any suggestions, or wants to help flesh out places, characters, etc., I'd be happy to hear it. Even if you've never read rice boy, I'm more than open to suggestions - again, I'm using rice boy as a starting point for the general plot and world, but I'm ultimately creating an original story (and one more suited for D&D). I have no qualms with changing things from the story in order to make for a better game.
PS: I just noticed, for the first time, that I typo'd when creating this username. I feel a wee bit silly...